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Abstract #1118

Detection of Immune Cell Infiltration and Visualization of Inflammatory Dilation on Myocardial Disorder Using Fluorescent Magnetic Nanoparticles

Hyeyoung Moon1, 2, Hyo Eun Park3, Jongeun Kang1, 4, Kiyuk Chang3, Kwan Soo Hong1, 4

1Division of MR research, Korea Basic Science Institute, Cheongwon-Gun, Chungcheongbuk-Do, Korea, Republic of; 2Bio-Analytical Science, University of Science and Technology, Daejeon, Korea, Republic of; 3Department of Internal Medicine, Catholic University, Seoul, Korea, Republic of; 4Graduate School of Analytical science and Technology, Chungnam National University, Daejeon, Korea, Republic of

In this study, we investigated whether PEGylated fluorescent magnetic nanoparticles (MNP) could detect the inflammatory areas in experimentally induced autoimmune myocarditis (EAM) rats with in vivo cardiac MRI. In addition, we examined the MNPs possibility if we apply to clinical research by exploring the inflammatory dilation and therapeutic effect.