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Abstract #1140

Iterative Three Compartment Model for Look-Locker Cardiac ASL Acquisition

Adrienne E. Campbell1, 2, Anthony N. Price3, Mark F. Lythgoe1, Roger J. Ordidge4, Dave L. Thomas5

1Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, University College London, London, United Kingdom; 2Department of Medical Physics and Bioengineering, University College London, London, United Kingdom; 3Robert Steiner MRI Unit, Imaging Science Department, Hammersmith Hostpital, Imperial College London, London, United Kingdom; 4Centre for Neuroscience, University of Melbourne, Melbourne, Australia; 5Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom

Look-Locker arterial spin labelling (ASL) is used for the measurement of myocardial perfusion in preclinical studies. Saturation effects from Look-Locker acquisition will become particularly relevant in the heart when acquiring multi-slice ASL data, which requires thicker slice-selective inversions and additional RF pulses. In this study, we have taken the preliminary steps toward developing a 3-compartment iterative ASL model for the heart which includes the effects of the Look-Locker acquisition, in order to model the ASL acquisition.