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Abstract #1145

A Theoretical Model Describing the Cine-ASL Perfusion Mapping Technique: Steadily-Pulsed Labeling Provides Better Acquisition Efficiency Than FAIR

Thibaut Capron1, Thomas Troalen1, Patrick J. Cozzone1, Monique Bernard1, Frank Kober1

1Centre de Rsonance Magntique Biologique et Mdicale (CRMBM), UMR CNRS N6612, Facult de Mdecine, Aix-Marseille Universit, Marseille, France

The FAIR-ASL method, applied to the heart, has key limitations due to the relaxation of the labeled magnetization during the experiment. We propose a new steadily-pulsed ASL experimental scheme that allows maintaining the tagged state, simultaneously with cine-imaging. We provide a theoretical description of such a scheme and show a close agreement with the behavior observed in a proof-of-concept experiment carried out in mice heart. The calculations thus allow for a reliable assessment of myocardial perfusion. Furthermore, theory predicts that the acquisition efficiency can be enhanced by a factor of 3 with respect to the widely used FAIR technique.