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Abstract #1168

In Vivo Assessment of Adventitial Vasa Vasorum in Patients with Symptomatic Carotid Plaques: A Dynamic Contrast-Enhanced MRI Study.

Jie Sun1, Yan Song2, William S. Kerwin1, Huijun Chen1, Dong Li3, Daniel S. Hippe1, Min Chen2, Cheng Zhou2, Thomas S. Hatsukami4, Chun Yuan1

1Radiology, University of Washington, Seattle, WA, United States; 2Radiology, Beijing Hospital, Beijing, China; 3Radiology, Anzhen Hospital, Beijing, China; 4Surgery, University of Washington, Seattle, WA, United States

Substantial evidence indicates that adventitial vasa vasorum (VV) is actively involved in the atherogenic process. However, non-invasive methods to study adventitial VV quantitatively are limited. This study characterized adventitial VV in symptomatic patients using dynamic contrast-enhanced MRI (DCE-MRI). Adventitial Ktrans derived from DCE-MRI was found to be closely associated with IPH and clinical symptom status. DCE-MRI provides a noninvasive way to study adventitial VV in patients and may be useful in understanding plaque progression or individual risk stratification.