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Abstract #1187

High Field In-Vivo PC-MRI to Quantify and Compare Regional and Local Pulse-Wave Velocity in the Right Common Carotid Artery in Mice

Volker Herold1, Alma Zerneck2, Alexander Gotschy1, Eberhard Rommel1, Wolfgang Rudolf Bauer2, Peter Michael Jakob1

1Experimental Physics 5, University of Wrzburg, Wrzburg, Bavaria, Germany; 2Medizinische Universittsklinik, University of Wrzburg

Quantification of the vessel wall function in mouse models by estimating the pulse wave velocity (PWV) has emerged as an important predictor of cardiovascular risk. Usually transit-time methods (TT) to quantify the averaged regional PWV and local PWV measurements using QA-methods (Q: volume flow; A: cross-sectional area) are applied. However, no comparison of these techniques have yet been performed with MR-based imaging in particular not in the carotid arteries. In this paper we present a multi-site-TT approach to calculate at the first time the regional PWV in the carotid artery and compare these results with local PWV values