Haiyan Ding1, 2, Laura Fernandez-de-Manuel1, 3, Michael Schr4, 5, Elliot R. McVeigh1, Henry Halperin6, M. Muz Zviman6, Daniel A. Herzka1
1Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States; 2Biomedical Engineering, Tsinghua University, Beijing, China; 3Biomedical Image Technologies Lab, ETSI Telecomunicacion, Universidad Politecnica de Madrid, and CIBER-BBN, Madrid, Spain; 4Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States; 5Philips Healthcare, Cleveland, OH, United States; 6Department of Medicine, Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, United States
The area of myocardium at risk (AAR) is defined as hypoperfused myocardium at the time of an ischemic episode, such as acute myocardial infarction (MI). To assess AAR, measures of both scar and edema must be combined. Late Gadolinium enhancement (LGE) with phase sensitive inversion recovery (PSIR) is a well-established method of delineating scar. Recently, quantitative 3D T2 mapping has been shown to be a robust method for visualizing edema. In this work it is shown that the combination of 3D respiratory navigator gated T2 Mapping and PSIR make high-resolution whole-heart AAR determination possible.
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