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Abstract #1225

Highly Accelerated in vivo Measurement of Local Pulse Wave Velocity in Mice Using a K-T BLAST QA-Method

Volker Herold1, Thomas Kampf1, Alexander Gotschy1, Felix Breuer2, Eberhard Rommel1, Wolfgang Rudolf Bauer3, Peter Michael Jakob1

1Experimental Physics 5, University of Wrzburg, Wrzburg, Bavaria, Germany; 2Research Center for Magnetic Resonance Bavaria; 3Medizinische Universittsklinik, University of Wrzburg

Local elastic properties of the murine arteries such as the pulse-wave-velocity (PWV) can be calculated using PC-MRI to quantify blood-flow (Q) and cross-sectional area changes (A) (QA-method). To calculate the PWV the measured Q and A pulses have to undergo a frequency low pass filtering step. Moreover, a short total measurement time is of paramount interest, in particular with varying cardiac cycles. We present a method which substitutes temporal low pass filtering by temporal undersampled data acquisition followed by a k-t BLAST reconstruction with the benefit of an almost 10 fold acceleration of data acquisition without compromising the PWV calculation.