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Abstract #1275

Measuring T1 of Chyme in the Ascending Colon in Health and Diarrhoea Predominant Irritable Bowel Syndrome

Caroline L. Hoad1, Klara Garsed2, Luca Marciani2, Eleanor F. Cox1, Carolyn Costigan1, Robin C. Spiller2, Penelope A. Gowland1

1Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

T1 of the chyme in the ascending colon (AC) was measured using an inversion recovery TrueFISP sequence in healthy volunteers and patients with diarrhoea predominant irritable bowel syndrome (IBS-D). Data was fitted to both 1-compartment and 2-compartment T1 models. IBS-D patients showed a higher mean T1 in the chyme of their AC than the healthy volunteers for both the 1-compartment and short component of the 2-compartment model. This difference may have been due to faster small bowel transit or a reduced rate of fluid absorption in the AC.