Abstract #1290

Mapping of Liver Function in Thioacetamide-Induced Rat Acute Liver Injury Using an Empirical Mathematical Model and Dynamic Contrast-Enhanced MRI with Gd-EOB-DTPA

Shigeyoshi Saito¹, Yuki Moriyama², Shuichiro Kobayashi², Ryota Ogihara², Daichi Koto², Akihiko Kitamura², Taro Matsushita², Motoko Nishiura², Kenya Murase²

¹Department of Medical Physics and Engineering,, Osaka University, Suita, , Osaka , Japan; ²Department of Medical Physics and Engineering,, Osaka University, Suita,, Osaka, Japan

Our purpose of this study was to evaluate thioacetamide (TAA)-induced acute liver injury in rats using an empirical mathematical model (EMM) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). DCE-MRI studies were performed using Gd-EOB-DTPA, 48 hours after TAA or saline injection. We calculated the rate of contrast uptake, the rate of contrast washout, the elimination half-life of relative enhancement (RE), the maximum RE, and the time to (REmax) (Tmax) from time-signal intensity curves using EMM. The EMM is useful for the assessment of TAA-induced rat acute liver injury using DCE-MRI with Gd-EOB-DTPA.