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Abstract #1290

Mapping of Liver Function in Thioacetamide-Induced Rat Acute Liver Injury Using an Empirical Mathematical Model and Dynamic Contrast-Enhanced MRI with Gd-EOB-DTPA

Shigeyoshi Saito1, Yuki Moriyama2, Shuichiro Kobayashi2, Ryota Ogihara2, Daichi Koto2, Akihiko Kitamura2, Taro Matsushita2, Motoko Nishiura2, Kenya Murase2

1Department of Medical Physics and Engineering,, Osaka University, Suita, , Osaka , Japan; 2Department of Medical Physics and Engineering,, Osaka University, Suita,, Osaka, Japan

Our purpose of this study was to evaluate thioacetamide (TAA)-induced acute liver injury in rats using an empirical mathematical model (EMM) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). DCE-MRI studies were performed using Gd-EOB-DTPA, 48 hours after TAA or saline injection. We calculated the rate of contrast uptake, the rate of contrast washout, the elimination half-life of relative enhancement (RE), the maximum RE, and the time to (REmax) (Tmax) from time-signal intensity curves using EMM. The EMM is useful for the assessment of TAA-induced rat acute liver injury using DCE-MRI with Gd-EOB-DTPA.