Abstract #1309

Assessment of Renal Function After Conformal Radiotherapy and Intensity Modulated Radiotherapy by Functional 1H-MR-Imaging and 23Na-MR-Imaging.

Stefan Haneder¹, Judit Boda-Heggemann², Simon Konstandin³, Lothar R. Schad³, Frederik Wenz², Frank Lohr², Stefan O. Schoenberg¹, Henrik J. Michaely¹

¹Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Mannheim, Baden-Wrttemberg, Germany; ²Department of Radiation Oncology, University Medical Center Mannheim, Mannheim, Baden-Wrttemberg, Germany; ³Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Baden-Wrttemberg, Germany

Conventional 3-dimensional conformal radiotherapy (3D-CRT) after gastric cancer results in ablative doses to the cranial part of the left kidney, while image-guided intensity-modulated radiotherapy (IG-IMRT) provides improved kidney sparing. Functional magnetic resonance imaging at 3.0T including BOLD, DWI and 23Na-imaging was used to evaluate renal status after radiotherapy with 3D-CRT or IG-IMRT. Marked morphological/functional effects were observed in high-dose areas (3DCRT) while no alteration in kidney function was observed in IG-IMRT patients who received lower doses of radiation. Functional MRI at 3.0T seems feasible for investigation of post-radiotherapeutic renal changes.