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Abstract #1313

Hemodynamic Effects of Furosemide on Renal Perfusion as Evaluated by Noninvasive ASL-MRI

Jing Wang1, Yudong Zhang2, Xiaoying Wang, 12, Jue Zhang1, 3, Jing Fang1, 3

1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 2Department of Radiology, Peking University First Hospital, Beijing, China; 3College of Engineering, Peking University, Beijing, China

In this study, short-term effects of furosemide on renal perfusion were investigated by using FAIR-ASL at 3T MR. Baseline and post ASL images were acquired on healthy subjects before and after furosemide administration to measure the renal hemodynamic response. Furosemide produced a remarkable reduction in medullar RBF, while cortical and global RBF changes did not reach a significant level. Furosemide administration is associated with a prominent decrease in the medullar blood perfusion, but its hemodynamic effects on the renal cortex still need further study, while ASL-MRI provides an alternative way to noninvasively monitor changes in renal function.