Abstract #1331

Tracer Kinetic Parameters Estimated with Rapid DCE-MRI in Patients with Muscle-Invasive Cancer of the Bladder Are Able to Distinguish Between the Effects of Neo-Adjuvant Chemotherapy and Residual Tumour

Stephanie Donaldson¹, Bernadette Carrington², Suzanne Bonington², Richard Cowan³, Jeanette Lyons³, David Buckley⁴

¹Christie Medical Physics and Engineering, The Christie, Manchester, Greater Manchester, United Kingdom; ²Department of Radiology, The Christie, Manchester, United Kingdom; ³Department of Clinical Oncology, The Christie, Manchester, United Kingdom; ⁴Division of Medical Physics, University of Leeds, Leeds, United Kingdom

Treatment of bladder cancer with chemotherapy and radiotherapy results in inflammation which mimics residual tumour on conventional MR images. Dynamic contrast-enhanced (DCE-) MRI was performed in eighteen patients following neo-adjuvant chemotherapy. Data obtained from abnormal areas observed on conventional MR images were analysed with a two-compartment exchange model to obtain estimates of perfusion and permeability. The descriptive parameter, relative signal intensity at 80 s (rSI80s) was calculated. The bladder was examined for evidence of residual tumour and/or post-chemotherapy effect. DCE-MRI parameters obtained in areas of residual tumour were significantly higher than those obtained in areas of post-chemotherapy effect.