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Abstract #1335

Positive Contrast Ultra-Short Echo Time Imaging (UTE) of Infiltrating Iron-Labeled Macrophages for Early Detection of Lung Inflammation in the Mouse

Klaus Strobel1, Verena Hoerr1, Florian Schmid1, Lydia Wachsmuth1, Cornelius Faber1

1University Hospital Mnster, Mnster, Germany

Preclinical diagnosis of lung inflammation with T2* weighed protocols after systemic application of super paramagnetic iron oxide nanoparticles (SPIOs) is considered impossible because of the strong intrinsic susceptibility effects between lung parenchyma and alveolar spaces. Here we implemented an ultra-short echo time (UTE) sequence and successfully detected positive contrast in the lung after systemic administration of SPIOs in a mouse model of lung inflammation.