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Abstract #1338

Imaging V/Q in Chronic Thromboembolic Pulmonary Hypertension with 3He and 1H MRI

Helen Marshall1, David G. Kiely2, David Capener1, Martin H. Deppe1, Juan Parra-Robles1, Andrew J. Swift1, Smitha Rajaram1, Judith Hurdman2, Robin Condliffe1, Charles A. Elliot1, Jim M. Wild1

1Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom; 2Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals Trust

In Chronic Thromboembolic Pulmonary Hypertension perfusion can be imaged using scintigraphy, CTPA or 1H MRI, but assessment of ventilation is usually limited to scintigraphy which has low spatial resolution and uses ionising radiation. 3He ventilation and 1H perfusion MRI were used to image V/Q matching in six CTEPH patients, one patient was scanned both pre and post endarterectomy. The perfused lung volume and area of V-Q intersection were greatly increased by endarterectomy. V/Q MRI is useful for the assessment of ventilation and perfusion in CTEPH, and could provide a sensitive non-ionising means of monitoring patient response to interventions.