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Abstract #1345

Ventilation-Perfusion Mismatch in COPD with or Without Emphysema: Comparison of Functional OE-MRI and Structural CT

Weijuan Zhang1, 2, Penny L. Hubbard1, 2, Eva Bondesson3, Lars Wigstrm4, Simon S. Young5, David Singh6, Geoffrey JM Parker1, 2, Josephine H. Naish1, 2

1Imaging Sciences, School of Cancer & Enabling Sciences, The University of Manchester, Manchester, United Kingdom; 2The Biomedical Imaging Institute, The University of Manchester, Manchester, United Kingdom; 3Semcon Drug Development Consulting, Lund, Sweden; 4AstraZeneca R&D, Lund, Sweden; 5AstraZeneca R&D, Chamwood, United Kingdom; 6University Hospital of South Manchester Foundation Trust, Manchester, United Kingdom

Single-slice coronal oxygen-enhanced MRI were performed in 24 patients with chronic obstructive pulmonary disease (COPD) and 12 healthy volunteers, from which color-coded V/Q maps were extracted by pixelwise model fitting. COPD lungs were then structurally classified into emphysematous and non-emphysematous subgroups according to percentage of low attenuation areas under -950 Hounsfield units in matched 2D CT images.