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Abstract #1348

Observation of Gravitational Dependence of Regional Fractional Ventilation in Human Lungs with 2D and 3D Multi-Breath Washout Imaging of 3He and 129Xe

MAGNA25Felix Clemens Horn1, Martin Heiner Deppe1, Helen Marshall1, Graham Norquay1, Juan Parra-Robles1, Jim Wild1

1University of Sheffield, Sheffield, South Yorkshire, United Kingdom

The effects of gravity in multiple-breath inert gas washout MRI of hyperpolarised 3He and 129Xe with 2D and 3D imaging are demonstrated in a volunteer at 1.5 T. To compare different washout experiments the regional fractional ventilation factor r (=% of gas exchanged per breath) was used. It is seen that the gravitational effects are irrespective of imaging sequence and gas type being used and the offset between r-values of different experiments is likely to be dependent upon the gas used, on sequence and respirational volume.