Abstract #1371

A Non-Invasive and Early Diagnosis of Primary Scelerosing Cholangitis Using MR Spectroscopy

Sanaz Mohajeri¹,², Tedros Bezabeh¹, Scott B. King¹, Omkar B. Ijare¹, M.A. Thomas³, Gerald Minuk², Jeremy Lipschitz², Allan B. Micflikier², Iain Kirkpatrick², Lawrence Ryner¹, Ian C.P. Smith¹

¹National Research Council, Institute for Biodiagnostics, Winnipeg, Manitoba, Canada; ²University of Manitoba, Winnipeg, Manitoba, Canada; ³University of California, Los Angeles

Cholestasis results from failure to clear bile from the liver into the duodenum. Prolonged cholestasis results in accumulation of bile salts and hepatocellular damage. Phosphatidylcholine and glycine/taurine conjugated bile acids may play a role in the pathophysiology of cholestasis. Primary Scelerosing Cholangitis (PSC) is a chronic cholestatic liver disorder with inflammation, narrowing and finally obstruction of bile ducts. Considering the success of in vivo 1-H MRS in detecting human bile components, we are comparing in this study 1-D and 2-D spectra of human bile in healthy volunteers and PSC patients obtained using a 3T clinical scanner and our home-built receive array coil.