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Abstract #1412

Longitudinal Characterization of Trabecular Bone Microstructure and Computational Biomechanics for Determining Treatment Effects in Postmenopausal Women

Yusuf A. Bhagat1, Maite Aznarez-Sanato1, Jeremy F. Magland1, Theresa M. Scattergood2, Peter J. Snyder2, Felix W. Wehrli1

1Laboratory for Structural NMR Imaging, University of Pennsylvania, Philadelphia, PA, United States; 2Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania, Philadelphia, PA, United States

Recent advances in high-resolution structural imaging of trabecular and cortical bone and the use of these data as input into micro-finite-element (FE) models have shown potential for assessing the effect of treatment in patients with osteoporosis. Here, we report baseline and 1 year follow-up data in an ongoing investigation of women with low bone density (N=15) receiving either zoledronic acid or teriparatide, conducted at 3T and 7T. The baseline data show moderate associations with pQCT bone density while FE-derived axial stiffness is strongly correlated with bone volume fraction at the same site. Finally, repeat data in select subjects indicate large anabolic effects.