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Abstract #1436

Skeletal Muscle Metabolism Measured at Rest and After Excercise in Obese Non-Diabetic Subjects

Ladislav Valkovic1, 2, Barbara Ukropcova3, Marek Chmelik1, Miroslav Balaz3, Martin Tkacov1, Wolfgang Bogner1, Albrecht Ingo Schmid4, Ivan Frollo2, Iwar Klimes3, Erika Zemkova5, Jozef Ukropec3, Siegfried Trattnig1, Martin Krk6

1MR Centre of Excellence, Department of Radiology, Medical University of Vienna, Vienna, Austria; 2Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia; 3Obesity section, Diabetes and Metabolic Disease Laboratory, Institute of Experimental Endocrynology, Slovak Academy of Sciences, Bratislava, Slovakia; 4Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria; 5Faculty of Physical Education and Sport, Commenius University, Bratislava, Slovakia; 6Division of Endocrynology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

In this study different parameters of muscle energy and oxidative metabolism in quadriceps of overweight to obese healthy subjects (n=8) were compared. Maximal oxidative flux (Qmax) was measured by time resolved 31P-MRS during post exercise recovery. Six minutes of exercise at ~30% of MVC resulted in substantial decrease of PCr without alteration of pH. Mean value of Qmax reached 0.48±0.10 mM/s. Basal flux through ATPase (FATP) at rest was measured by magnetization transfer 31P-MRS experiment. Mean value of FATP was 0.23±0.09 mM/s. At this stage positive trend, but no significant correlation (r=0.535, p=0.19) was detected between Qmax and FATP.