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Abstract #1507

Combination of MR Spectroscopic and Diffusion Weighted Imaging of the Prostate for the Prediction of Tumor Aggressiveness

Gregor Thrmer1, Josephin Otto1, Christian Schrder1, Nikita Garnov1, Martin Reiss-Zimmermann1, Lars-Christian Horn2, Minh Do3, Jens-Uwe Stolzenburg3, Michael Moche1, Thomas Kahn1, Harald Busse1

1Dept. of Diagnostic and Interventional Radiology, Leipzig University Hospital, Leipzig, Saxony, Germany; 2Institute of Pathology, Division of Breast, Urogenital and Perinatal Pathology, University of Leipzig, Leipzig; 3Dept. of Urology, Leipzig University Hospital, Leipzig, Saxony, Germany

Active surveillance (AS) is currently discussed as an alternative to radical therapy for patients with low-risk prostate cancer. This option requires an accurate and reproducible technique to monitor the progress of the disease. Transrectal ultrasound-guided biopsy is only moderately suited because of its invasive nature and a substantial amount (40%) of undergrading. Multiparametric MRI, on the other hand, can provide quantitative parameters of tissue function that may help to assess cancer aggressiveness. This preliminary work evaluates the predictive value of combined DWI and MR spectroscopic parameters to discriminate indolent from aggressive carcinoma.