Abstract #1507

Combination of MR Spectroscopic and Diffusion Weighted Imaging of the Prostate for the Prediction of Tumor Aggressiveness

Gregor Thrmer¹, Josephin Otto¹, Christian Schrder¹, Nikita Garnov¹, Martin Reiss-Zimmermann¹, Lars-Christian Horn², Minh Do³, Jens-Uwe Stolzenburg³, Michael Moche¹, Thomas Kahn¹, Harald Busse¹

¹Dept. of Diagnostic and Interventional Radiology, Leipzig University Hospital, Leipzig, Saxony, Germany; ²Institute of Pathology, Division of Breast, Urogenital and Perinatal Pathology, University of Leipzig, Leipzig; ³Dept. of Urology, Leipzig University Hospital, Leipzig, Saxony, Germany

Active surveillance (AS) is currently discussed as an alternative to radical therapy for patients with low-risk prostate cancer. This option requires an accurate and reproducible technique to monitor the progress of the disease. Transrectal ultrasound-guided biopsy is only moderately suited because of its invasive nature and a substantial amount (40%) of undergrading. Multiparametric MRI, on the other hand, can provide quantitative parameters of tissue function that may help to assess cancer aggressiveness. This preliminary work evaluates the predictive value of combined DWI and MR spectroscopic parameters to discriminate indolent from aggressive carcinoma.