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Abstract #1516

The Initial Clinical Application of Arterial Spin Labeling Perfusion MRI in Prostate Cancer

Wenchao Cai1, Feiyu Li1, Jing Wang2, Jue Zhang2, 3, Xiaoying Wang1, 2, Xuexiang Jiang1

1Department of Radiology, Peking University First Hospital, Beijing, China; 2Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 3College of Engineering, Peking University, Beijing, China

Introduction:Pulsed arterial spin labeling (PASL) MRI is a non-invasive imaging tool capable of quantitatively measuring the microvascular perfusion characteristics of tissue. Purpose:We applied the PASL technique to detect the prostate cancer and to compare the differences blood flow(BF) values between the malignant and normal prostate peripheral zones. Methods:Six patients with pathologically confirmed prostate cancer were recruited to undergo the PASL examination with different invertion time(TI 1000/1200/1400/1600msec).Results: The mean BFs determined by PASL MRI with different TI in the prostate cancer were significantly higher than those in noncancerous regions (P<0.05, Paired T-test).Conclusion: This study demonstrates that PASL sequence can be used to evaluate the difference of BF value between cancer and noncancerous tissue in prostate.