Wenchao Cai1, Feiyu Li1, Jing Wang2, Jue Zhang2, 3, Xiaoying Wang1, 2, Xuexiang Jiang1
1Department of Radiology, Peking University First Hospital, Beijing, China; 2Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 3College of Engineering, Peking University, Beijing, China
Introduction:Pulsed arterial spin labeling (PASL) MRI is a non-invasive imaging tool capable of quantitatively measuring the microvascular perfusion characteristics of tissue. Purpose:We applied the PASL technique to detect the prostate cancer and to compare the differences blood flow(BF) values between the malignant and normal prostate peripheral zones. Methods:Six patients with pathologically confirmed prostate cancer were recruited to undergo the PASL examination with different invertion time(TI 1000/1200/1400/1600msec).Results: The mean BFs determined by PASL MRI with different TI in the prostate cancer were significantly higher than those in noncancerous regions (P<0.05, Paired T-test).Conclusion: This study demonstrates that PASL sequence can be used to evaluate the difference of BF value between cancer and noncancerous tissue in prostate.