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Abstract #1522

Mapping of Oxygen by Imaging Lipids Relaxation Enhancement (MOBILE) in Experimental Tumor Models: Comparison with R2*, R1 H2O, and OxyLite Fiber Optic Probes.

Benedicte F. Jordan1, Julie Magat1, Elif Ozel1, Florence Colliez1, Anne-Catherine Fruytier1, Valerie Marchand1, Lionel Mignion1, Caroline Bouzin2, Olivier Feron2, Bernard Gallez1

1Biomedical Magnetic Resonance Group, Universit Catholique de Louvain, Brussels, Belgium; 2Pole of Pharmacotherapy, Universit Catholique de Louvain, Brussels, Belgium

There is a critical need for methods able to monitor dynamically and noninvasively tumor oxygenation. The purpose of the current work was to compare the MOBILE technique, a method developed to map variations in oxygenation based on the changes in the relaxation properties of the tissue lipids by exploiting the higher solubility property of oxygen in lipids than in water, with R2*, R1 H2O, and simultaneous quantitative oxygen measurements using fluorescence quenching fiber optic probes. Changes in tumor oxygenation were induced by an hyperoxic breathing challenge in order to determine correlations between the response assessed using each technique.