Benjamin Lemasson1, Stefanie Galbn2, Fei Li1, Kevin Heist1, Alnawaz Rehemtulla1, 2, Craig Galbn1, Brian Ross1
1Radiology, University of Michigan, Ann Arbor, MI, United States; 2Radiation Oncology, University of Michigan, Ann Arbor, MI, United States
The goal of this study was to evaluate the functional diffusion map (fDM) as a biomarker of tumor recurrence on an animal-by-animal basis following different doses of radiation (1G, 2G and 4G) on a genetically engineered murine GBM model. Tumor size and fDM were monitor daily for a week and then every two days. We observed a large inter- and intra-group variability of time-to-recurrence. The maximum fDMrADC+ values measured during radiation therapy was correlated strongly to time-to-recurrence (R2=0.85). fDMrADC+ technique may serve as a biomarker of tumor recurrence that is insensitive to the response heterogeneity typically observed in GBM.