Rama Jayasundar1, Gaurav Sharma1, Shyam S. Chauhan2, Thirumurty Velpandian3
1Department of NMR and MRI, All India Institute of Medical Sciences, New Delhi, India; 2Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India; 3Department of Occular Pharmacology, All India Institute of Medical Sciences, New Delhi, Delhi, India
The study evaluated the metabolic profiling, elemental analysis and anticancer potential on four polyherbal formulations namely KG, VK, MK and GTK using NMR, LIBS and MTT assay, respectively. Antioxident potential of formulations was carried out using FRAP assay. Amongst four formulations maximum cytotoxicity was observed for KG (IC50 22.48 lower case Greek mug/ml)followed by MK (IC50 27.58 lower case Greek mug/ml). Using FRAP assay maximum antioxidant potential was achieved for VK (17.0 lower case Greek muM Fe++g-1) amongst four. KG and MK formulations were selected for characterization through NMR Spectroscopy, which revealed the chemical indentification of metabolites to explore pharmacological action. LIBS data supports antioxident properties of formulations.
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