Caleb Roberts1, Geoff J. Parker1, Ahmad Mirza2, Andrew Jackson3, Yvonne Watson1, Susan Cheung1, Giovanni Buonaccorsi1, Josephine H. Naish1
1Biomedical Imaging Institute, The University of Manchester, Manchester, Greater Manchester, United Kingdom; 2Departments of Gastrointestinal Surgery and Histopathology, University Hospital of South Manchester, Manchester, Greater Manchester, United Kingdom; 3Clinical Oncology, University Hospitals Southampton NHS Foundation Trust, Southampton, Hampshire, United Kingdom
There is a need to develop imaging methods that can assess treatment response and help individualise therapy in patients with oesophageal cancer. We explore the utility of dynamic contrast-enhanced MRI in a pilot study of 5 patients with oesophageal cancer. Each patient underwent two 3D DCE-MRI scans, each separated by a course of radical chemo radiotherapy. All patients showed significant treatment response demonstrated by changes in post-treatment pharmacokinetic parameters. We have successfully applied 3D DCE-MRI in oesophageal cancer and demonstrated its potential to assess treatment response.
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