Steven P. Allen1, William W. Roberts2, Timothy L. Hall1, Charles A. Cain1, Luis Hernandez-Garcia1
1Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States; 2Department of Urology, University of Michigan, Ann Arbor, MI, United States
Ultrasound based cavitation can non-invasively fractionate tissue (histotripsy) down to sub-organelle granularity. It is unknown how bio-effects may alter in vivo histotripsy lesions. Here, we use T1 and T2 weighted MRI of harvested prostates to characterize the in vivo histotripsy lesion into three zones: a liquefied focal zone, a margin of partially disrupted tissue, and a hemorrhage zone of negligible damage.