Abstract #1582

Characterization of the in vivo Histotripsy Lesion Using High Field MRI

Steven P. Allen¹, William W. Roberts², Timothy L. Hall¹, Charles A. Cain¹, Luis Hernandez-Garcia¹

¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States; ²Department of Urology, University of Michigan, Ann Arbor, MI, United States

Ultrasound based cavitation can non-invasively fractionate tissue (histotripsy) down to sub-organelle granularity. It is unknown how bio-effects may alter in vivo histotripsy lesions. Here, we use T1 and T2 weighted MRI of harvested prostates to characterize the in vivo histotripsy lesion into three zones: a liquefied focal zone, a margin of partially disrupted tissue, and a hemorrhage zone of negligible damage.