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Abstract #1598

Retrospective R1 Atlas Mapping of Brain Infusions

Do P.M. Tromp1, Marina E. Emborg1, Samuel A. Hurley1, Nagesh Adluru1, Martin L. Brady2, Raghu Raghavan2, Ken Kubota3, Andrew L. Alexander1

1University of Wisconsin, Madison, WI, United States; 2Therataxis, Baltimore, MD, United States; 3Kinetics Foundation, Los Altos, CA, United States

New treatments of brain diseases like Parkinsons disease and brain tumors are focusing on direct and local delivery of therapeutics in the brain. Convection-enhanced delivery (CED) has been proposed to increase the distribution and dose of therapeutic agents in a target area beyond simple diffusion. In this project we developed an image analysis framework to retrospectively generate a normalized statistical atlas of infusion studies, which will facilitate the investigation of how different infusion factors influence the treatment outcome.