Feng Zhang1, Yanfeng Meng1, Stephanie Soriano1, Patrick Willis1, David Glickerman1, Xiaoming Yang1
1Radiology, University of Washington, Seattle, WA, United States
This study was to develop a new technique of intrabiliary MRI-guided local agent delivery. We validated the feasibility of using MR to monitor, in vivo, intrabiliary delivery of MGd into the pig common bile duct walls of 6 pigs, which was confirmed by subsequent MRI-histology correlation. This new technique may open new revenues for MR-guided intrabiliary local delivery of therapeutics, such as genes and drugs, to treat malignant pancreatobiliary diseases.