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Abstract #1610

Intrabiliary MRI-Monitored Local Delivery of Motexafin Gadolinium

Feng Zhang1, Yanfeng Meng1, Stephanie Soriano1, Patrick Willis1, David Glickerman1, Xiaoming Yang1

1Radiology, University of Washington, Seattle, WA, United States

This study was to develop a new technique of intrabiliary MRI-guided local agent delivery. We validated the feasibility of using MR to monitor, in vivo, intrabiliary delivery of MGd into the pig common bile duct walls of 6 pigs, which was confirmed by subsequent MRI-histology correlation. This new technique may open new revenues for MR-guided intrabiliary local delivery of therapeutics, such as genes and drugs, to treat malignant pancreatobiliary diseases.