Meeting Banner
Abstract #1621

T1 Modulation of CEST in a Eu(III)-DOTA-Tetraamide-Bis(Nitroxyl) Complex

James S. Ratnakar1, Subha Viswanathan1, Matthew E. Merritt1, Chien-Yuan Lin1, A. Dean Sherry1, Zoltan Kovacs1

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

The CEST properties of a Eu(III)-DOTA-tetraamide complex having two covalently appended TEMPO (2,2,6,6-(tetramethylpiperidin-1-yl)oxyl) units can be turned on under reducing conditions due to the reduction of the paramagnetic TEMPO moieties to its diamagnetic hydroxylamine derivative.