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Abstract #1630

Liver Directing Uridine-Based Paramagnetic Amphiphilic T1 MRI Contrast Agent with High Relaxivity

Hyunseung Lee1, Hyeyoung Moon1, Sankarprasad Bhuniya2, Jong Seung Kim2, Kwan Soo Hong1, 3

1Division of MR Research, Korea Basic Science Institute, Cheongwon-gun, Chungcheongbuk-Do, Korea, Republic of; 2Department of Chemistry, Korea University, Seoul, Korea, Republic of; 3Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea, Republic of

The chelated Gd3+ metal ion improves imaging contrast by increasing the longitudinal relaxation time (T1) of proximal water protons, which appear brighter in the T1-weighted image. Current advanced medical diagnosis techniques stipulate high-resolution images with a high magnetic field scanner; however, current Gd3+-based contrast agents (CAs) ligated with polyamino carboxylate are incapable of meeting requirements as they do not have optimal relaxivity profiles at high magnetic fields.