Xiaoli X. Liu1, Achuthamangalam B. Madhankumar1, Patti A. Miller2, Kari A. Duck1, James R. Connor1, Qing X. Yang2
1Neurosurgery, The Pennsylvania State College of Medicine, Hershey, PA, United States; 2Radiology, The Pennsylvania State College of Medicine, Hershey, PA, United States
A formulation liposome has been developed to encapsulate Gd-DTPA (Liposome-Gd) for targeted imaging of glioma. However, it is not clear whether Liposme-Gd is able to cross intact blood brain barrier (BBB) so that it can be used for detecting tumors at early stage when treatment is more effective. Our data obtained from normal mice with intact BBB demonstrated the first and direct evidence that liposome-Gd are capable of crossing BBB, which creates a great potential application in imaging of gliomas.
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