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Abstract #1635

Multifunctional Nanoparticles for the Monitoring and Assessment of Therapeutic Delivery

Gavin D. Kenny1, Bhavana S. Solanky2, Italo A. Sanhueza3, Nicholas J. Mitchell3, Frederick Campbell3, Katharina Welser3, Mauro Botta4, Alethea B. Tabor3, Helen C. Hailes3, Mark F. Lythgoe1

1Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom; 2Institute of Neurology, UCL, London, United Kingdom; 3Department of Chemistry, UCL, London, United Kingdom; 4Dipartimento di Scienze dell 'Ambiente e della Vita, Universit del Piemonte Orientale "Amedeo Avogadro", Alessandria, Italy

Nanoparticles are widely used as therapeutic delivery vectors in a wide range of diseases, due to their versatility. However, accurate monitoring of distribution is challenging using current techniques. Here, we have investigated the use of a novel fluorinated peptide incorporated into a nanoparticle for the monitoring of distribution and assessment of therapeutic delivery by taking advantage of the lack of endogenous 19F signal.