Assessment of Early Vascular Response Under Abraxane Therapy Using DCE-MRI and 18F-FPPRGD2 PET

Xilin Sun¹, Dan Wang¹, Baozhong Shen¹

The mechanism of action of Abraxane is complex, and some reports exist that Abraxane triggers reactionary angiogenesis. Our previous studies had shown some alterations of tumor vessels from immature to mature in morphological and molecular characteristics by Abraxane, and the integrin-specific PET tracer 18F-FPPRGD2 (investigational new drug 104150) can noninvasive monitoring the integrin avb3 level. The purpose of this study is to further investigate a comprehensive vascular response (molecular level and functional such as permeability and penetration) during Abraxane therapy with combined dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and 18F-FPPRGD2 PET.