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Abstract #1658

Phase Contrast MR Microscopy to Study Glioma Invasion in vivo at High Field

Nicoleta Baxan1, Stella Maria Carro2, Roberto Ferrarese2, Dominik von Elverfeldt1, Markus Bredel2, 3, Wilfried Reichardt1

1Department of Radiology, University Medical Center Freiburg, Freiburg, BW, Germany; 2Department of Neurosurgery, University Medical Center Freiburg, Freiburg, BW, Germany; 3Department of Radiation Oncology, University of Alabama, Birmingham, United States

As the brain is composed of a variety of cell type that vary strongly according to their anatomical location, an accurate assessment of the implantation site plays an important role in the investigation of growth characteristics and physiology of tumors. This study was performed to determine to what extend high-resolution MR microscopy enables to accurately determine the early fate of implanted glioma cells and the injection tract under in vivo conditions. The presented approach based on the MR signal phase can be an efficient alternative to replace the need of cell labeling that might potentially alter cellular characteristics.