Galen D. Reed1, Peder E.Z. Larson1, Cornelius von Morze1, Robert Bok1, Michael Lustig2, Adam B. Kerr3, John M. Pauly3, John Kurhanewicz1, Daniel B. Vigneron1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; 2Electrical Engineering and Computer Sciences, University of California Berkeley; 3Electrical Engineering, Stanford University
An echo planar imaging sequence for simultaneous dynamic imaging of multiple hyperpolarized 13C compounds is presented. Frequency separation was achieved by spatial mis-registration in the phase-encoded direction by the appropriate choice of echo spacing. Suppression of the pyruvate-hydrate and alanine resonances was achieved using an optimized spectral-spatial RF waveform. Dynamic imaging was demonstrated in a transgenic mouse cancer model. Images of pyruvate and lactate were acquired after hyperpolarized pyruvate infusion. Images of lactate and HP001 were acquired after simultanous infusion of hyperpolarized pyruvate and HP001.