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Abstract #1681

Optimization of Polarization Transfer Sequence Timing for Parahydrogen Induced Polarization

Dirk Graafen1, 2, Michael Ryan Hansen2, Laura Maria Schreiber1, Kerstin Mnnemann2

1Section of Medical Physics, Johannes Gutenberg University Medical Center, Mainz, Germany; 2Max Planck Institute for Polymer Research, Mainz, Germany

The aim of the study was to optimize the timing of a PH-INEPT+ sequence for 13C1-Hydroxyethylproprionate (HEP) to enable optimal polarization transfer from hyperpolarized protons using parahydrogen induced polarization (PHIP) to Carbon-13. Spin dynamics simulations showed the different sequence timing behavior of a thermally polarized and a PHIP polarized molecule. In comparison, for this molecule the optimal τ 1 delay of the PH-INEPT+ sequence is ~4ms for the thermal polarization whereas it is ~27.5ms for the hyperpolarized state. Experiments in a 7T spectrometer reproduce the simulation results adequately.