Abstract #1706

1H/31P Polarization Transfer at 7 and 9.4 Tesla for Improved Specific Detection of Phosphomono- And -Diesters in Human Breast and Breast Tumor Models.

Jannie P. Wijnen¹,², Lu Jiang¹, Wybe J.M. van der Kemp², Dennis W.J. Klomp², Kristine Glunde¹

¹Johns Hopkins University in vivo Cellular and Molecular Imaging Center,Russell H. Morgan Department, Johns Hopkins University School of Medicine, Baltimore, MD, United States; ²Department of Radiology, University Medical Centre Utrecht, Utrecht, Netherlands

Here we have demonstrated that using polarization transfer (PT) methods such as refocused insensitive nuclei enhanced by polarization transfer (RINEPT) and its adiabatic version (BINEPT) at 7 and 9.4Tesla can improve the 31P magnetic resonance spectroscopy (MRS) detection of phosphomono- and diesters in human breasts and breast tumor xenograft models in vivo. BINEPT ³¹P MRS was able to detect partially resolved phosphoethanolamine, phosphocholine, glycerophosphoethanolamine and glyerophosphocholine because it is insensitive to unwanted broad resonances from macromolecules that do not posses H-P J-coupling, without compromising SNR compared to direct ³¹P MRS.