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Abstract #1728

31P MR Spectroscopic Imaging with Nuclear Overhauser Enhancement at 7T in the Human Prostate

Miriam W. Lagemaat1, Marnix C. Maas2, Thiele Kobus2, Andreas K. Bitz3, 4, Mark J. van Uden2, Stephan Orzada3, 4, Arend Heerschap2, Tom W J Scheenen2

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen , Netherlands; 2Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 3Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany; 4Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany

In Vivo 31P MRSI of the human prostate is potentially important in characterizing prostate cancer. We determined T1 relaxation times of the 31P metabolites and evaluated the NOE effect in the healthy human prostate at 7T to optimize the protocol in terms of sensitivity and measurement time for clinical use. A 31P MRSI sequence with a TR of 1.5s, flip angle of 45 and nominal voxel size of 1.9cm3 produces well-resolved spectra with up to 38% signal increase by NOE.