Meeting Banner
Abstract #1732

In-Vivo Localized Magnetic Resonance Spectroscopy in Small Animals Using Parallel Spatially Selective Excitation of Arbitrarily Shaped Volumes

Peter Ullmann1, Johannes T. Schneider1, Sarah R. Herrmann1, Wolfgang Ruhm1

1Bruker BioSpin MRI GmbH, Ettlingen, Germany

Segmented parallel excitation (PEX) offers great potential for localized magnetic resonance spectroscopy (MRS) by allowing the excitation of arbitrarily shaped voxels which can be used to mitigate partial-volume effects and to increase SNR. In this study PEX-based spectroscopy was performed in a rat brain in vivo to assess the applicability of PEX for high-field small-animal MRS and to compare it to conventional selection methods. Results obtained at 9.4 T demonstrate that complex-shaped voxels adapted to the brain anatomy can be excited with good spatial selectivity and that spectra can be acquired thereof with improved SNR compared to cuboid-shaped spectroscopy voxels.