Refocused Double Quantum Editing for Lactate Detection in the Human Calf Muscle at 7T

Vincent Oltman Boer¹, Peter R. Luijten¹, Dennis W.J. Klomp¹

Double quantum filters suffer from severe signal loss if a long double quantum time is required. This is especially the case for applications in lipid rich environments such as fatty tumors or muscle tissue. Therefore a refocused double quantum filter was used that allows for the use of arbitrarily long dephasing gradients only at the cost of additional T2 loss. The lactate signal at rest and during exercise was detected in the human calf muscle after determination of the minimum required gradient area for complete lipid dephasing.