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Abstract #1748

Regional Alterations of the Brain Macromolecule Resonances Investigated in the Mouse Brain Using an Improved Method for the Pre-Processing of the Macromolecular Signal

Mlanie Craveiro1, Cristina Cudalbu1, Rolf Gruetter1, 2

1Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Departments of Radiology, Universities of Lausanne and Geneva, Switzerland

An accurate macromolecule (MM) knowledge is necessary to a reliable metabolite quantification. However, as MM signal acquisition is time-consuming and needs further pre-processing steps, a unique rodent MM signal is commonly used for quantifying mouse and rat brain spectra. We developed in this study a novel and accurate method to remove metabolite residuals from MM signals prior quantification. Moreover, we showed that potential regional alterations of the MM signal in the mouse brain and alterations between mouse and rat MM signals have no significant effects on metabolite quantification.