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Abstract #1760

Age and Breast Density Dependence of Choline in Breasts of Healthy Female Subjects Found Using 3D-MRSI

SUMMA25Lenka Minarikova1, Wolfgang Bogner1, Marek Chmelik1, Katja Pinker-Domenig1, Hubert Bickel1, Thomas Helbich1, Siegfried Trattnig1, Stephan Gruber1

1Centre of Excellence HF MR, Department of Radiology, Medical University of Vienna, Vienna, Austria

In previous studies, using single-voxel MR-spectroscopy or mutlivoxel MR-spectroscopy imaging (MRSI), choline signal with higher SNR was defined as a marker of malignancy in breast lesions. We present that choline signal can be detected using MRSI with high SNR in a large fraction of normal breast tissue and the SNR demonstrates an exponential correlation with breast density and age of the subject. Therefore, breast MRS-data from younger subjects with breast lesions should be interpreted with caution.