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Abstract #1764

Lipid Content and Composition Differ in Adipose Tissues and Liver of Ob/ob Mice

Qiong Ye1, Alexander Fuchs1, Markus Rudin1, 2

1Institute for Biomedical Engineering, Zrich, Switzerland; 2Institute of Pharmacology and Toxicology, Zrich, Switzerland

Both fat content and their composition in adipose tissues and liver were accessed non-invasively with proton magnetic resonance spectroscopy in 34 weeks old ob/ob mice, a well-established murine model of obesity, using 9.4T system. In this work, spectra from different adipose tissues (subcutaneous fat pads at neck and belly as well as visceral fat) and from liver were compared. Liver showed a significant lower amount of lipids amount than three adipose tissues compartments. Lipids from lower belly displayed a higher degree of saturation. Furthermore, the fraction of polyunsaturated and monounsaturated lipids was found different among adipose tissues and liver.