Abstract #1769

Reduced Glutamatergic Metabolism in Mice Cortex with Different Level of Alcohol Exposure

Anant Bahadur Patel¹, Pandichelvam Veeraiah¹

¹NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India

Effects of alcohol exposure via oral route on cerebral metabolism is not fully understood. In this study, we have investigated glutamatergic and GABAergic metabolism in cerebral cortex in mice exposed with different dose of alcohol via intra-gastric route. Acute treatment with alcohol at higher dose increased level of cortical GABA. Alcohol exposure selectively attenuates the excitatory activity without much changes in inhibitory function.