Abstract #1771

Neurochemical Profile of Patients with Type 1 Diabetes Measured by 1H-MRS at 4 T

Silvia Mangia¹, Anjali Kumar², Amir Moheet², Lynn Eberly³, Rachel Roberts³, Elizabeth Seaquist², Ivan Tkac¹

¹CMRR - Dept. of Radiology, University of Minnesota, Minneapolis, MN, United States; ²Dept. of Medicine, University of Minnesota, Minneapolis, MN, United States; ³Div. of Biostatistics, University of Minnesota, Minneapolis, MN, United States

In this work we investigated differences in the neurochemical profiles of subjects with Type 1 Diabetes Mellitus (T1DM) relative to similarly aged healthy controls at the same level of plasma glucose using the increased sensitivity and spectral resolution of 1H-MRS at 4T. Data were analyzed from a group of 14 patients with long-standing T1DM (>10 years) and a group of 32 healthy controls. Levels of NAA and glutamate were lower by 6% in the grey matter of T1DM as compared to controls (p<0.005 and p<0.05, respectively), supporting the hypothesis that T1DM is associated with neuronal loss or dysfunction.