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Abstract #1775

Functional Diffusion-Weighted Spectroscopy (FDWS) of the Human Brain at 7T

Francesca Branzoli1, Aranee Techawiboonwong2, Sebastian Aussenhofer1, Andrew Webb1, Itamar Ronen1

1C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands; 2Department of Electrical Engineering, Mahidol University, Bangkok, Thailand

Here we propose functional Diffusion-Weighted Spectroscopy (fDWS) as a new method to investigate compartment-specific microstructural and metabolic changes related to neuronal activation. In this method a time series of alternating diffusion and non-diffusion weighted spectra is acquired, yielding a time-resolved series of apparent diffusion coefficient (ADC) values of metabolites correlated with neuronal activation. Especially, the detected changes in tCr and tCho ADCs can be exploited as a viable probe for brain activity, providing a tool for direct measurement of metabolic and microstructural changes during neuronal activation.