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Abstract #1779

Different Types of COSY Applied to Study Glutamate and Glutamine in a Clinical Scanner

Saadallah Ramadan1, Hui Jun Liao Liao2, Alexander Lin2, Carolyn Mountford2, 3

1Centre for MR in Health, School of Health Sciences, University of Newcastle, Callaghan, New South Wales, Australia; 2Center for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, United States; 3Centre for MR in Healt, University of Newcastle, Callaghan, NSW, Australia

: Different types of COSY spectroscopy (adiabatic COSY, constant-time COSY, and localized COSY) are evaluated with a series of phantoms with variable concentrations of glutamate (Glu)/glutamine (Gln), to find out which sequence is the most optimal in determining relative amounts of Glu and Gln. While cross peaks obtained in the three types of COSY correlated well with total pool of Glu/Gln, they did not correlate with ratio of Glu to Gln.