1H MR Spectroscopy of High Grade Prostate Cancer

Thiele Kobus¹, Jack Van Asten¹, Alan Wright¹, Arend Heerschap¹, Tom Scheenen¹

PRESS and semi-LASER based ¹H MRSI was performed in 17 patients with highly aggressive prostate cancer. The maximum choline plus creatine over citrate ratio and the maximum choline over creatine ratio were determined. Both metabolite ratios were very abnormal in all patients. The absence of frequency-selective lipid suppression in the semi-LASER sequence enables detection of metabolites in a broader frequency range. This enabled detection of an unassigned peak at 2.05 ppm. Although the identity of this resonance remains unknown, it was excluded that this resonance belonged to either spermine, glutamate or glutamine.