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Abstract #1790

31P MRS as a Potential Biomarker for Fibromyalgia

Mikael Fredrik Forsgren1, 2, Ann Bengtsson3, Olof Dahlqvist Leinhard1, 2, Birgitta Sren3, Vaclav Brandejsky4, 5, Eva Lund1, 5, Peter Lundberg1, 2

1Depts of Radiation Physics, Linkping University and Radiation Physics, UHL County Council of Ostergotland, Linkping, Sweden; 2Center for Medical Image Science and Visualization (CMIV), Linkping University, Linkping, Sweden; 3Depts of Rheumatology, University Hospital and Faculty of Health Sciences, Linkping, Sweden; 4Depts Clinical Research and Radiology, University Bern, Bern, Switzerland; 5Depts of Medical and Health Sciences (IMH), Division of Radiological Sciences, Linkping University, Linkping, Sweden

An impaired muscle energy metabolism in fibromyalgia (FM) patients has been suggested. The purpose of this study was to non-invasively analyze the content of phsophogens in the resting quadriceps muscle in FM patents compared to healthy controls using quantitative 31P MRS. Using an external reference for normalization we found significant group differences in PCr and NTP-Mg, suggesting that quantitative 31P MRS might be used as a biomarker for FM.