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Abstract #1795

Assessment of Neurochemical Alterations in Rats Exposed to Long-Term Alcohol Treatment

Do-Wan Lee1, Sang-Young Kim1, Hyunseung Lee2, Taehyeong Lee3, Changbum Yoo3, Jae-Hwa Kim4, Chi-Bong Choi5, Hwi-Yool Kim3, Dai-Jin Kim4, 6, Kwan-Soo Hong2, Bo-Young Choe1

1Department of Biomedical Engineering and Research Institute of Biomedical Engineering, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of; 2MRI Team, Korea Basic Science Institute; 3Department of Veterinary Surgery, Konkuk University of Korea; 4Department of Biomedical Science, College of Medicine, The Catholic University of Korea; 5Department of Veterinary Diagnostic Radiology, Dr. PET Animal Medical Center; 6Department of Psychiatry, Seoul St. Marys Hospital, College of Medicine, The Catholic University of Korea

This study was aimed to investigate the cerebral neurochemical effects of long-term alcohol exposure on the adolescent rat frontal cortex. Our results show that GPC+PCh, Ins, Glx concentrations and (GPC+PCh)/NAA levels were significantly differed in frontal cortex of ethanol group. In particular, GPC+PCh concentrations and (GPC+PCh)/NAA levels showed most significant differences in ethanol group. Increased GPC+PCh concentrations and (GPC+PCh)/NAA levels may indicate that increased turnover of phosphatidylcholine and/or changed adaptive mechanism in frontal cortex of rat brain. Therefore, increased GPC+PCh concentrations and (GPC+PCh)/NAA ratio levels of frontal cortex might be utilized as key marker in long-term adolescent alcohol intoxication.